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Takeda failed to do so other than an FDA required reference in the Actos package insert to 2005 study results showing that four times as many participants taking Actos had developed bladder cancers, but Takeda also inserted minimizing language stating a causal link had not been established between Actos and bladder cancer.
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Rechallenge with the other antidiabetic medications would have been appropriate.
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Globally, there are now more than 20 polypills containing metformin, and the list is likely to continue to grow as new diabetes drugs are developed.
FDA Approves First Ever Inhaled Insulin Combination Product for Treatment of Diabetes.
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Of those, 128 were eligible to be analyzed and 68 patients were treated with metformin alone, 32 with insulin and 28 with the combination of metformin and insulin.
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In the second Actos lawsuit to go before a jury, lawyers argue that Takeda Pharmaceuticals put profits above public safety by failing to warn about the side effects of Actos.
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Linagliptin used in combination with insulin to treat diabetes has not been studied to date.
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High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial Infarction.
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Some doctors recommend it as a follow-up after FPG, if the latter test results are normal but the patient has symptoms or risk factors of diabetes.
This is an eye condition associated with diabetic retinopathy that causes swelling in the macular area of the retina.
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The diabetes drug pioglitazone (Actos) increases the risk of bladder cancer in people who take it for a year or longer, the Food and Drug Administration announced yesterday.
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