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Can Benadryl help RLS? Finally, many common drugs can aggravate RLS symptoms, including caffeine, alcohol, and nicotine; the antihistamine drug diphenhydramine (Benadryl), which is found in many over-the-counter cold, allergy, and sleeping pills; prescription antidepressants such as amitriptyline (Elavil), fluoxetine (Prozac), and
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