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Does Accutane affect hormones? Isotretinoin influences pituitary hormone levels in acne patients. Karadag AS(1), Ertugrul DT, Tutal E, Akin KO. Several hormones have been linked to the pathogenesis of acne. In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne.