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TM and ciliary SM cells are thought to be the major target cells in the aqueous humor outflow pathway for glaucoma treatments.

Glaucoma is a neurodegenerative disease in which the retinal ganglion cells and optic nerve axons are vulnerable to degeneration and may also be amenable to neuroprotection.

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Despite some variation in the findings, all these studies suggest that treatment with a fixed combination is generally well tolerated and effective in treatment-naïve patients, with no serious safety concerns.

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