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Therefore, antihypertensive treatment for morning hypertension is likely to offer greater benefit in preventing cardiovascular events.

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The main outcome of the Randomized Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study was published in 2011.

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Olmesartan stops the formation of Angiotensin-II which in turn causes relaxation of blood vessels or reduces the Vasoconstriction and the secretion of aldosterone.

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Olmesartan Medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types.

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Mercurio said guidelines already recommend asking women if theyve had high blood pressure during pregnancy.

The Randomized Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study showed that 40 mg Olmesartan medoxomil (OM) versus placebo delayed microalbuminuria onset in patients with type 2 diabetes and normoalbuminuria.

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Meier methods were used to construct cumulative time-to-event curves for the two groups, and the primary comparison was based on a log-rank test.

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The early recognition and appropriate management of neuropathy in the patient with diabetes is important for a number of reasons: 1) nondiabetic neuropathies may be present in patients with diabetes and may be treatable; 2) a number of treatment options exist for symptomatic diabetic neuropathy; 3) up to 50% of DPN may be asymptomatic and patients are at risk for insensate injury to their feet; 4) autonomic neuropathy and particularly cardiovascular autonomic neuropathy is associated with substantial morbidity and even mortality.

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ECG findings are ST-segment elevation in leads II, III and aVF, with reciprocal ST-segment depression in leads I and aVL.

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No studies of impairment of fertility with olmesartan medoxomil-hydrochlorothiazide have been conducted.

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In the second half of the double-blind phase, patients who had not achieved BP control had their treatment uptitrated and showed further significant increases in BP reduction by the end of this second 8-week treatment phase.

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Wienen W, Entzeroth M, van Meel JCA, et al: A review on telmisartan: a novel, long-acting angiotensin II-receptor antagonist.

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