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In a few cases, therapy with oral rifampin and fusidic acid was an important component of therapy for the successful treatment of hVISA and VISA infections in patients who had failed vancomycin therapy ().
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The fusidic acid steady-state concentrations in serum (S) and skin suction blister fluid (SBF) after oral doses of 250 and 500 mg administered twice daily for 6 days, as film-coated tablets of sodium fusidate, were studied in eight healthy subjects.
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In Australia and some other parts of the world, the use of oral combination therapy with rifampin and fusidic acid is the mainstay of therapy for complicated MRSA infections requiring prolonged nonparenteral therapy.
Type 1 chloramphenicol acetyltransferase (CAT-I) competitively binds to fusidic acid resulting in inactivation by sequestration ().
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