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OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your professional.
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As for the enzymes, a minimum dose could be taken daily for the entire lifespan, but for disease states one would need to take "therapeutic doses" until recovery.
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Bisoprolol is eliminated by two equally effective routes, that is, about half of the dose is metabolized to three inactive polar metabolites in the liver that are then eliminated by the kidneys.
Following administration of racemic bisoprolol, the area under the plasma concentration-time curve and the elimination half-life are slightly higher for (S)-bisoprolol than for (R)-bisoprolol (Horikiri et al.
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This study was a randomized, single-blind, two-period, two-sequence crossover study that included 18 healthy adult male and female subjects under fasting condition.
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Secondary end points were all-cause mortality, all-cause hospital admission, cardiovascular mortality, acute non-fatal MI, combined end point (cardiovascular mortality plus acute non-fatal MI), cardiovascular hospital admission, and permanent premature treatment withdrawals.
Alternatively, such additional pharmaceutical compounds may be provided in a separate formulation and co-administered to a subject along with an enriched (S)-bisoprolol composition according to the present invention.
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