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My older brother has had schizoprenia since he was 14 years old in 1970's. He has been on many, many medicines with some or little success. He was then put on Clozaril in his thirty's, what a miracle Clozaril was. He was able to live a almost normal life for over 10 years and within 3 days his life went from happy to hell again, because of his blood test result, we tried to get him back on it but due to the special list with people who have reactions to it are not able to ever take it again. My brother is one of the lucky one's though he has a family that totally supports him and encourages him to live and do the best that he can. He lives in a adult facility that takes care of his needs and makes sure he gets his medicines.



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Clozapine tablet is only available through a restricted program under a REMS called the Clozapine REMS Program because of the risk of severe neutropenia.

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Nighttime hallucinations and confusion (also referred to as psychosis) may result from any combination of cognitive impairment, dopaminergic medications, age and PD-related vision changes and lack of sleep.

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The following adverse reactions have been identified during post-approval use of clozapine.

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Symptoms of illness Something someone tells you about what they are feeling or experiencing such as high temperature, feeling sick to your stomach, weakness, or being very tired, etc.

Clozapine is the drug of choice in treatment-resistant schizophrenia.

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QUESTION: "The nurse meets with the client and his wife to discuss depression and the client's medication.

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Leading or organizing activities is too overwhelming for the client and can result in increased anxiety, fear, and withdrawal.

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Vitamin C deficiency may occur but it is not a hallmark symptom of the disorder.

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Patients should be monitored appropriately and observed closely for worsening of their symptoms, suicidality or changes in their behavior, especially during the first few months of treatment, and at times of dose changes.

The first specific aim of this study is to test the efficacy and safety of clozapine compared to placebo in a double-blind study of children and adolescents with treatment refractory BPD.

At higher doses, the drug can provide hallucinatory or “out of body” experiences; some people find the dreamlike state frightening, others believe it to be spiritual.

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An Eight-Week, Multinational, Multicenter, Randomized Double-blind, Placebo-controlled study, with XXXX as an Active Control to Evaluate the Efficacy, Safety and Tolerability of XXXX 100 mg in Elderly Patients with Major Depressive Disorder March 2007 to November 2007.

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Those at greatest risk of experiencing antiepileptic drug-related seizure exacerbation are children with severe epileptic encephalopathies, patients with high frequency of seizures or several types of seizures, and patients on polytherapy (Nakken and Johannessen 2008).

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Studies comparing clozapine with the second generation antipsychotic drugs amisulpride, aripiprazole and sertindole are currently completely missing and are therefore mandatory.

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Inform about risks of orthostatic hypotension and syncope, especially during the period of initial dose titration; instruct to strictly follow the instructions of the physician for dosage and administration.

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Standardized differences were calculated for the matched analytic cohort to examine covariate balance () between individuals treated with clozapine or standard antipsychotics.

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Treatment also can help prevent future episodes if the individual is willing to work on personal issues and develop healthy habits.

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QUESTION: "After teaching a client about lorazepam (Ativan), which of the following client statements indicates the need for further teaching?

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Lithium or valproate is a first-line treatment for rapid cycling.

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In 2002, the drug received the FDA approval after showing positive results in independent clinical researches.

This response ignores the parents' concerns and diminishes trust in the nurse by not offering accurate information about the disorder.

They have also been found to help with regular manic episodes.

Ketoacidosis may become life-threatening if it is not treated at an early stage.

In a small clinical trial involving 40 people conducted in 2006, researchers randomly assigned the participants to receive either Lamictal or a placebo for up to 26 weeks.

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In one case the symptoms were transient (predominantly compulsive), in the second case the symptoms reduced with reduction in dose of clozapine (symptoms were only obsessive doubts), and the third case required stoppage of clozapine due to severity of obsessive symptoms (both obsessions and compulsions).

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Although prescribers may feel that they have no option but to use high-dose antipsychotic polypharmacy in certain situations, such as with complex and dangerous patients, the question remains as to why they do not monitor patients appropriately.

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