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I would like to share my opinion concerning Hydrea, I hope it would be useful to someone who still haven't found an effective medication or is not sure about the choice. I have been on this medication (1 capsule a day) since the year 2010. I was diagnosed with Myeloperliferative Disease about 7 years ago and since that time I have tried several medications that were supposed to bring my platelets and hemoglobin levels down. And to be honest some of other cancer meds were more or less effective, but I inevitably had to stop the treatment courses and ask my doctor to switch me to another med because of the side effects I couldn't tolerate. Most awful side effects were unbearable pain in my muscles and bones that would keep me awake for many nights on end. I also had nausea and fatigue that would keep me away from my usual duties. I do have a serious illness but I want to stay active and to live my life the way I am used to. And when medications produce some effect but make me suffer and forget about normal life, then these meds are not for me. With Hydrea everything is quite different. I have side effects but they are not that serious for me to stop treatment. Besides the drug is really good for its purpose. So, while looking for something more effective or better to say while waiting for the pharmacists to create a new med, I am more than ok with Hydrea.
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I have essential thrombocytemia and have been on Hydrea for more than 5 years. The dosage differs from time to time, according to my blood tests. Actually I undergo blood tests every months since the time I was diagnosed with the disease. This is not the first thrombocytemia medication I am on, but this is by far the best one. With Hydrea I have least side effects and it provides excellent results on my platelets level. However I have some nausea and occasional headaches I feel much better with Hydrea than with any other med. I do hope that one day I will be able to find a more effective treatment that will help me conquer the illness but in general I am happy with Hydrea as it makes my quality of life so much higher. My doctor is also satisfied with the results we achieve when on Hydrea and he plans to continue this treatment course. I wish him lots of luck!)

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The prescribed dose should be administered orally, once daily with a meal and a large glass of water.

Additional efforts, such as medication calendars, pill containers, and encouragement from family members, also can be beneficial.

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The fact that it often takes 3 to 6 months of treatment for the patient to have a clinical response decreases adherence.

Although several pharmacological agents have been studied for the treatment of SCD, the only drug currently approved by the US Food and Drug Administration (FDA) for the treatment of SCD is hydroxyurea.

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Daily stress and mood and their association with pain, health-care use, and school activity in adolescents with sickle cell disease.

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The authors also are grateful for the support and vision of Clarice Reid, MD, and the supervision and guidance of the Drug Safety Monitoring Board and Duane Bonds, MD, Program Leader for the Sickle Cell Section of the Heart Lung and Blood Institute.

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Ensure better translation of findings to the patient and caregiver populations by using culturally or language-appropriate written and visual materials.

All guidelines summarized by NGC and hosted on our site are produced under the auspices of medical specialty societies, relevant professional associations, public or private organizations, other government agencies, health care organizations or plans, and similar entities.

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Hydroxyurea can prevent some of the vasoocclusive complications of sickle cell anemia, an effect that is due, at least partially, to its ability to increase HbF levels.

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Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Cladribine significantly decreases the phospho-STAT3 (P-STAT3) levels in a dose-dependent manner, but has no effect on the total STAT3 protein levels.

Indirubin is from the indigo plant and is included in a traditional Chinese herb formula that has been used historically to treat CML.

The difference that one can find between a brand medication and a generic lies in the name, shape and price.

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Baseline elevation of HbF should not affect the decision to initiate hydroxyurea therapy.

We agree with the editorial accompanying the guidelines that other parameters such as fatigue, dyspnea, mechanical ventilation, or the use of low SvO2 (venous oxygen saturation) are unproven.

Several nurses also told the surgeon that the seizure-like activity appeared to be more than a dystonic reaction to promethazine, although none of the nurses had ever witnessed such a reaction.

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Anecdotes have been published describing young patients with SCA who developed malignancy while taking hydroxyurea therapy.

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HU screening and prescription.

They may ask you to hold your breath or take shallow breaths during the treatment.

In the multicenter study looking at the treatment of acute chest syndrome, 72 percent of the patients received red cell transfusions to treat this acute event.

As part of the MSH, demographic and quality of life measures were obtained from all study subjects to assess the impact of hydroxyurea therapy on the patients' perception of pain, stamina and the day-to-day activities of living.

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Type IV is delayed-type reactions with cell-mediated hypersensitivity, which result in contact dermatitis, exanthematous reactions, and photoallergic reactions.

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Urinary markers of bone resorption, pyridinoline and deoxypyridinoline, are increased in sickle cell patients with further increments during painful crisis.

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Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease.

Caution should be taken when applying the cream to avoid the eyes, ears, nostrils, and mouth.

Because both patients and providers have identified side effects as a concern that limits the use of hydroxyurea, more information on the incidence and severity of these side effects is essential for both patients and providers to make informed choices.

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This hospital runs a complementary cancer clinic offering treatment with homeopathic remedies and Iscador (mistletoe therapy).

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In subsequent years, clinical trials demonstrated the efficacy of this drug for the treatment of CML, psoriasis, and polycythemia vera.

If you miss a dose of hydroxyurea, take it as soon as you remember.

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Exposing people to what researchers have called a “scapegoat stimulus” just before the administration of chemotherapy can direct the food aversion to the “scapegoat” food instead of more important parts of the diet.

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Prospective life span data for children taking HU are not yet available due to later uptake into pediatric trials.

If cutaneous vasculitic ulcers occur, institute treatment and discontinue Hydrea.

The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.

Second malignancies in patients with essential thrombocythaemia treated with busulphan and hydroxyurea: long-term follow-up of a randomized clinical trial.

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However, this determination was based on conditional haplotype tests that excluded uninformative haplotypes.

The Sickle Cell Clinical Research Network is an NHLBI-supported network for phase III clinical trials.

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In the adult patient, all infections must be treated promptly with broad-spectrum antibiotics.

Vaso-occlusive crisis involving organs such as the penis or lungs are considered an emergency and treated with red-blood cell transfusions.

For both men and women: Do not conceive a child (get pregnant) while taking fulvestrant.

Any product information or advice on this site is provided for informational purposes only and should not be used as a substitute for the advice provided by your own medical practitioners.

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The pheresis service needs superb nurses who can place a large-bore peripheral IV in any patient.

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Although all of the patients were 18 and over, only 79 percent said they were already going to doctor's appointments on their own.

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Treatments for sickle cell include antibiotics, pain management and blood transfusions.

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Only a minority of patients with locoregionally advanced disease can undergo adequate surgical resection, and the outcomes were poor with respect to survival and organ preservation.

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However, they are often poorly tolerated, potentially oncogenic, and lack proof of effectiveness comparable with HU (recently reviewed in ref.

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Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease.

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Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children.

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For example, in the RTOG 97-03 trial, the FHX platform was as efficacious as cisplatin and paclitaxel combination therapy and superior to combined cisplatin and 5-FU therapy, with a 2-year overall survival of 69% being reported.

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There is concern that long-term hydroxyurea therapy may be carcinogenic or leukemogenic, because some other antineoplastic agents have such effects.

When they added these five variants to a model previously designed by Platt to predict disease severity, which also factors in age, sex, degree of anemia and HbF levels, the model's predictive ability was enhanced.

Treatment of metastatic and recurrent cervix cancer with chemotherapy: a randomised trial comparing hydroxyurea with cisdiamminedichloro-platinum plus methotrexate.

The molecular basis of hemoglobin switching, including more detailed descriptions of the role of many of the genes involved in this process, has been recently reviewed.

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Despite the improvement with concurrent chemoradiotherapy, overall survival remained poor.

What side effects may I notice from receiving this medicine?

However, because the initiating methionine is not part of the mature beta-globin protein, the long-standing convention of numbering the amino acids is to begin with the next amino acid (Val).

Serial biopsies every 3 to 5 days can also be helpful in differentiating the two disorders (Crider et al.

After either a stem cell or bone marrow transplant, the healthy bone marrow cells begin to grow and produce healthy blood cells.

Each unit of red cells contains nearly a year worth of dietary iron.

The patient was a 47-year-old African American woman who had learned she had HbSC disease only 6 weeks earlier.

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The study involved two newly-infected people who took ddI and hydroxyurea (standard doses of both).

In addition to the variation of the phenotype resulting from allelic heterogeneity at the beta globin locus, from the effect of alpha or gamma globin gene mutation or from coinheritance of heterocellular HPFH delineated above, the phenotype of beta-thalassemia could also be modified by the action of genetic factors mapping outside the globin gene cluster and not influencing the HbF.

If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting this drug.

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Evaluation of cerebrospinal fluid (CSF) during screening is only required if there is a clinical suspicion of CNS involvement by leukemia during screening.

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Inform about risk of cutaneous vasculitic toxicities and secondary malignancies (eg, leukemia, skin cancers); advise use of sun protection.

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Studies currently under way should provide more information regarding the benefit of hydroxyurea in preventing organ damage and additional sickle cell disease outcomes.

Adults with severe SCD can take a medicine called hydroxyurea to help reduce the number of pain crises.

MPD patients taking HU.

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Bone marrow transplantation for sickle cell disease offers promise.

The majority of patients with sickle cell disease (SCD) have some degree of baseline anemia due to ongoing hemolysis.

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Patients continued using SMART to record clinical symptoms, pain intensity, location and perceived severity, and treatment strategies for at least 28 days.

However, the study group consisted of nurses who were employed in surgical or medical floors of a general hospital.

SCD mice with a single dose of HU (intravenously), concomitantly with TNF-α, and quantified leukocyte responses by intravital microscopy at 3 hours after treatment.

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As has been pointed out already, almost every real physician asks their patients about (and, sad to say, lectures them about) their diet, exercise, etc.

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Sometimes I wondered what her outcome would be, and called a doctor friend who helped me cope with the unknown.

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In this case, doctors try to treat the complication causing the pain.

Predictors of fetal hemoglobin response to hydroxyurea were most frequently reported.

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Possible decreased elimination; reduced dosage and close monitoring of hematologic parameters is recommended.

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The first pregnancy test will be performed at screening (within 7 days prior to first study drug administration).

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Hydroxyurea also increases the production of fetal hemoglobin, via an unknown mechanism of action, which increases overall hemoglobin levels and decreases sickling in patients with sickle cell anemia.

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Hydroxyurea exerts bi-modal dose-dependent effects on erythropoiesis in human cultured erythroid cells via distinct pathways.

In deoxygenated sickle hemoglobin, an interaction between the Glu6Val residue and the complementary regions on adjacent molecules can result in the formation of highly ordered insoluble molecular polymers that aggregate and distort the shape of the red blood cells, making them brittle and poorly deformable, increasing adherence to the endothelium.

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The hallmark symptoms of the disease, however, are the episodes of severe acute pain, called vaso-occlusive crises (or sickle cell crises), that the individual can experience.

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Several pharmacologic compounds including 5-azacytidine, decytabine, and butyrate derivatives have had disappointing results in clinical trials.

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El uso de hydroxyurea puede aumentar su riesgo de desarrollar otros tipos de cáncer, como leucemia o cáncer de la piel.

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They can take it from any vein but usually use one in the inner part of your elbow.

The following tips will help you, or someone you know with sickle cell disease, stay as healthy as possible.

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Because the rate of polymerization is so exquisitely dependent on the hemoglobin S concentration, any treatment that lowers the mean corpuscular hemoglobin concentration has a sound rationale.

Baseline QOL results were available on all 299 MSH patients according to originally assigned treatment group.

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Take hydroxyurea at around the same time every day.

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Studies were selected if they (a) enrolled patients with SCD-related pulmonary hypertension, (b) compared patients who received targeted PAH therapy to patients who received no targeted PAH therapy, and (c) measured patient-important outcomes.

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