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Sanofi-Aventis, Bridgewater, NJ) versus mitoxantrone for hormone-resistant prostate cancer, higher testosterone levels among obese men suggested incomplete gonadal suppression with current androgen ablation therapies.

PFS and PSA PFS in patients with locally advanced disease compared with standard care alone.

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We conclude by discussing the potential implications of these findings for understanding resistance and optimizing response to new agents targeting the AR-axis for prostate cancer therapy.

The FXXLF motif mediates androgen receptor-specific interactions with coregulators.

Surgery is very challenging because of j-pouch and adhesions; he had 3 incidents of obstructions that resulted in surgery.

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In patients with prostate cancer, disease progression can have serious clinical consequences, such as painful bone metastases, spinal cord compression, pathological fractures and urinary dysfunction.

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Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy.

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Cases of death or hospitalization due to severe liver injury (hepatic failure) have been reported post-marketing in association with the use of Bicalutamide.

In this situation, neoadjuvant hormone therapy is used to shrink the prostate gland to enable better implantation of radioactive seeds so that the right dose of radiation can be administered.

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Hot flashes are among the most common distressing side effects of ADT.

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CASODEX (bicalutamide) is highly bound and is extensively metabolized.

Androgen deprivation therapy in castrate-resistant prostate cancer: how important is GnRH agonist backbone therapy?

Despite theses facts, neoadjuvant hormonal therapy remains essentially the sole method used to reduce prostate volume prior to prostate brachytherapy.

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After treatment, LH release is transiently increased up to 2 weeks after the initial dose, referred to as the flare or hormonal surge.

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My only choice is hormone therapy, but the side effects are horrible.

The blood may be donated by another person or it may have been taken from the patient and stored until needed.

DDE, relate structurally to the therapeutic antiandrogen flutamide.

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