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If bleeding from an ulcer does not stop with medication and supportive care (like fluids and blood transfusion), a physician called a gastroenterologist will perform an endoscopy.

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Pantoprazole 40 mg and 80 mg were compared in a randomized double-blind study in 192 out-patients with stage II or III (Savary-Miller classification) reflux oesophagitis.

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All patients were asked to keep a symptom diary, in which they recorded the severity of symptoms (heartburn and acid reflux) prior to and during the first 7 d of PPI administration.

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AUC and C max have been used successfully to establish the most beneficial PPI exposure in adults.

During 6 days of repeated administration of pantoprazole sodium for injection in patients with Zollinger-Ellison Syndrome, consistent changes of serum gastrin concentrations from baseline were not observed.

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David Geffen School of Medicine at UCLA, CURE: Digestive Diseases Research Center, Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, Building 115, Room 316, 11301 Wilshire Blvd, Los Angeles, CA.

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In fact, Ekpe and Jacobsen investigated the stability of pantoprazole in a variety of laboratory-grade buffers, and their results are therefore not useful for predicting stability of the drug in commonly used IV solutions.

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The tablet form of pantoprazole is released in the intestine to prevent breakdown of the medication by stomach acids.

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The clinical relevance of the finding is unknown, but risks and benefits are recommended for consideration in determining the use of therapy for the mother and child.

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In a single prospective, randomized, single-blind study in 164 patients undergoing endoscopic submucosal dissection for gastric neoplasm, IV pantoprazole delayed bleeding compared with IV famotidine.

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